RayBiotech Mouse Anti-Human Pro-BNP [+Biotin] Antibody Gene ID 4879, 50 µg 130-10070B-50

Description

Brain natriuretic peptide (BNP) is a polypeptide of 134-amino acids comprised of a 26-amino acid signal peptide (Met1-Ser26), a 76-amino acid N-terminal fragment (NT-proBNP) (His27-Arg102), and a 32-amino acid mature polypeptide of brain natriuretic peptide 32 (BNP-32)(Ser103-His134). BNP-32 is secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes). BNP-32 is co-secreted along with NT-proBNP which is biologically inactive. Both BNP-32 and NT-proBNP markers are used for screening, diagnosis of acute congestive heart failure (CHF). The plasma concentrations of both BNP and NTproBNP are also typically increased in patients with asymptomatic/symptomatic left ventricular dysfunction.. Immunogen: Immunogen was recombinant protein derived from proBNP. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G/A affinity chromatography.. Isotype: IgG1.